Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
154  structures 6545  species 0  interactions 24146  sequences 135  architectures

Clan: EDD (CL0245)


EDD superfamily Add an annotation

The EDD superfamily was identified as an evolutionarily conserved domain (EDD) common to three different folds: mannose transporter EIIA domain (EIIA-man), dihydroxyacetone kinase (Dak), and DegV [1]. Both Dak and EIIA-man perform similar phosphotransfer reactions, suggesting a phosphotransferase activity for the DegV-like family of proteins, whose function other than lipid binding revealed in the crystal structure remains unknown [1].

This clan contains 4 families and the total number of domains in the clan is 24146. The clan was built by A Bateman.

Literature references

  1. Kinch LN, Cheek S, Grishin NV; , Protein Sci. 2005;14:360-367.: EDD, a novel phosphotransferase domain common to mannose transporter EIIA, dihydroxyacetone kinase, and DegV. PUBMED:15632288 EPMC:15632288
  2. Schulze-Gahmen U, Pelaschier J, Yokota H, Kim R, Kim SH; , Proteins 2003;50:526-530.: Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein. PUBMED:12577257 EPMC:12577257


This clan contains the following 4 member families:

Dak1 Dak1_2 DegV EIIA-man

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DegV (PF02645) 7912 (32.8%) View
EIIA-man (PF03610) 6755 (28.0%) View
Dak1 (PF02733) 6390 (26.5%) View
Dak1_2 (PF13684) 3089 (12.8%) View
Total: 4 Total: 24146 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...