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1281  structures 9438  species 0  interactions 130791  sequences 1673  architectures

Clan: NTP_transf (CL0260)


Nucleotidyltransferase superfamily Add an annotation

This clan contains a diverse set of nucleotidyltransferase enzymes.

This clan contains 33 families and the total number of domains in the clan is 130791. The clan was built by A Bateman.


This clan contains the following 33 member families:

AbiEii Adenyl_cycl_N Adenyl_transf Aminoglyc_resit DNA_pol3_alpha DNA_pol_B_palm DUF2204 DUF294 DUF4269 DUF6036 DZF GlnE GrpB LicD Mab-21 MdcG Nrap Nrap_D4 NTF-like NTP_transf_2 NTP_transf_5 NTP_transf_6 NTP_transf_7 NTP_transf_8 Polbeta PolyA_pol Pox_polyA_pol RelA_SpoT RlaP RsfS SMODS Tam41_Mmp37 TUTase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NTP_transf_2 (PF01909) 18223 (13.9%) View
DNA_pol3_alpha (PF07733) 15863 (12.1%) View
RelA_SpoT (PF04607) 15208 (11.6%) View
PolyA_pol (PF01743) 12895 (9.9%) View
RsfS (PF02410) 9344 (7.1%) View
GlnE (PF03710) 8797 (6.7%) View
AbiEii (PF08843) 4981 (3.8%) View
Polbeta (PF18765) 4801 (3.7%) View
LicD (PF04991) 4098 (3.1%) View
DNA_pol_B_palm (PF14792) 3509 (2.7%) View
DZF (PF07528) 3472 (2.7%) View
DUF294 (PF03445) 3232 (2.5%) View
GrpB (PF04229) 3060 (2.3%) View
Mab-21 (PF03281) 2565 (2.0%) View
NTP_transf_5 (PF14907) 2359 (1.8%) View
RlaP (PF10127) 2339 (1.8%) View
TUTase (PF19088) 2313 (1.8%) View
Pfam family Num. domains Alignment
Tam41_Mmp37 (PF09139) 2102 (1.6%) View
Nrap_D4 (PF17405) 1870 (1.4%) View
NTP_transf_7 (PF07984) 1754 (1.3%) View
Nrap (PF03813) 1752 (1.3%) View
NTP_transf_6 (PF06042) 1048 (0.8%) View
SMODS (PF18144) 910 (0.7%) View
Adenyl_transf (PF04439) 819 (0.6%) View
DUF6036 (PF19502) 601 (0.5%) View
NTP_transf_8 (PF12281) 491 (0.4%) View
Adenyl_cycl_N (PF12633) 487 (0.4%) View
MdcG (PF10620) 461 (0.4%) View
Aminoglyc_resit (PF10706) 404 (0.3%) View
NTF-like (PF14540) 385 (0.3%) View
DUF4269 (PF14091) 317 (0.2%) View
DUF2204 (PF09970) 286 (0.2%) View
Pox_polyA_pol (PF03296) 45 (0.0%) View
Total: 33 Total: 130791 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...