Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1187  structures 9190  species 0  interactions 125113  sequences 1120  architectures

Clan: NUDIX (CL0261)


NUDIX superfamily Add an annotation

This superfamily contains the NUDIX family and one related family.

This clan contains 10 families and the total number of domains in the clan is 125113. The clan was built by A Bateman.

Literature references

  1. Gunawardana D, Likic VA, Gayler KR;, Comp Funct Genomics. 2009:820381. Epub 2009; [Epub ahead of print]: A Comprehensive Bioinformatics Analysis of the Nudix Superfamily in Arabidopsis thaliana. PUBMED:19590748 EPMC:19590748


This clan contains the following 10 member families:

DUF4743 DUF4916 Hexose_dehydrat MRP-L46 NUDIX NUDIX-like NUDIX_2 NUDIX_4 NUDIX_5 Nudix_hydro

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NUDIX (PF00293) 105053 (84.0%) View
NUDIX_4 (PF14815) 7364 (5.9%) View
NUDIX-like (PF09296) 3963 (3.2%) View
NUDIX_2 (PF13869) 2061 (1.6%) View
Nudix_hydro (PF18290) 1744 (1.4%) View
DUF4743 (PF15916) 1600 (1.3%) View
MRP-L46 (PF11788) 1260 (1.0%) View
Hexose_dehydrat (PF03559) 844 (0.7%) View
DUF4916 (PF16262) 718 (0.6%) View
NUDIX_5 (PF16705) 506 (0.4%) View
Total: 10 Total: 125113 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...