Summary
His-Me finger endonuclease superfamily
This superfamily defined originally by SCOP contains a diverse range of endonucleases. Later Grishin identified the MH1 domain as belonging to the superfamily [1].
This clan contains 24 families and the total number of domains in the clan is 58590. The clan was built by A Bateman.
Literature references
- Grishin NV; , J Mol Biol. 2001;307:31-37.: Mh1 domain of Smad is a degraded homing endonuclease. PUBMED:11243801 EPMC:11243801
Members
This clan contains the following 24 member families:
AHH Colicin-DNase DFF40 DUF1524 DUF968 Endonuclea_NS_2 Endonuclease_1 Endonuclease_7 Endonuclease_NS GH-E His_Me_b4a2 HNH HNH_2 HNH_3 HNH_4 HNH_5 HNHc_6 ICEA LHH MH1 NinG RecA_dep_nuc WHH zf-His_Me_endonExternal database links
SCOP: | 54060 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
HNH (PF01844) | 13273 (22.7%) | View |
MH1 (PF03165) | 8893 (15.2%) | View |
Endonuclease_NS (PF01223) | 7686 (13.1%) | View |
HNH_2 (PF13391) | 5648 (9.6%) | View |
DUF1524 (PF07510) | 5046 (8.6%) | View |
HNH_5 (PF14279) | 4509 (7.7%) | View |
HNH_3 (PF13392) | 3953 (6.7%) | View |
Endonuclease_1 (PF04231) | 2439 (4.2%) | View |
HNH_4 (PF13395) | 1565 (2.7%) | View |
Endonuclease_7 (PF02945) | 1366 (2.3%) | View |
Endonuclea_NS_2 (PF13930) | 1331 (2.3%) | View |
AHH (PF14412) | 589 (1.0%) | View |
WHH (PF14414) | 510 (0.9%) | View |
continued |
Pfam family | Num. domains | Alignment |
---|---|---|
DFF40 (PF09230) | 464 (0.8%) | View |
NinG (PF05766) | 264 (0.5%) | View |
HNHc_6 (PF16784) | 212 (0.4%) | View |
Colicin-DNase (PF12639) | 211 (0.4%) | View |
LHH (PF14411) | 177 (0.3%) | View |
GH-E (PF14410) | 136 (0.2%) | View |
zf-His_Me_endon (PF05551) | 121 (0.2%) | View |
DUF968 (PF06147) | 102 (0.2%) | View |
RecA_dep_nuc (PF16786) | 67 (0.1%) | View |
ICEA (PF05315) | 25 (0.0%) | View |
His_Me_b4a2 (PF18275) | 3 (0.0%) | View |
Total: 24 | Total: 58590 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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