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469  structures 7754  species 0  interactions 204038  sequences 6035  architectures

Clan: Nucleot_cyclase (CL0276)


Nucleotide cyclase superfamily Add an annotation

This superfamily includes adenylyl cyclase and the GGDEF domain [1].

This clan contains 8 families and the total number of domains in the clan is 204038. The clan was built by A Bateman.

Literature references

  1. Pei J, Grishin NV; , Proteins 2001;42:210-216.: GGDEF domain is homologous to adenylyl cyclase. PUBMED:11119645 EPMC:11119645


This clan contains the following 8 member families:

Adcy_cons_dom Cmr2_N EAL GCH_III GGDEF GGDEF_2 Guanylate_cyc mCpol

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GGDEF (PF00990) 94435 (46.3%) View
EAL (PF00563) 50612 (24.8%) View
Guanylate_cyc (PF00211) 41583 (20.4%) View
GGDEF_2 (PF17853) 13122 (6.4%) View
Adcy_cons_dom (PF06327) 3527 (1.7%) View
Cmr2_N (PF12469) 412 (0.2%) View
GCH_III (PF05165) 244 (0.1%) View
mCpol (PF18182) 103 (0.1%) View
Total: 8 Total: 204038 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...