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32  structures 5122  species 0  interactions 13516  sequences 195  architectures

Clan: AIG2 (CL0278)


AIG2/ChaC-like superfamily Add an annotation

The structure consists of a five-stranded beta-barrel surrounded by two alpha-helices and a small beta-sheet. Conservation of residues in a hydrophilic cavity able to bind small ligands in some members suggests that this may also serve as an active site.

This clan contains 3 families and the total number of domains in the clan is 13516. The clan was built by A Bateman.

Literature references

  1. Lytle BL, Peterson FC, Tyler EM, Newman CL, Vinarov DA, Markley JL, Volkman BF; , Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006;62:490-493.: Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family. PUBMED:16754964 EPMC:16754964
  2. Aramini JM, Swapna GV, Huang YJ, Rajan PK, Xiao R, Shastry R, Acton TB, Cort JR, Kennedy MA, Montelione GT; , J Biomol NMR. 2005;33:197-197.: 1H, 13C, and 15N resonance assignments for Escherichia coli ytfP, a member of the broadly conserved UPF0131 protein domain family. PUBMED:16331424 EPMC:16331424


This clan contains the following 3 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GGACT (PF06094) 6908 (51.1%) View
ChaC (PF04752) 4339 (32.1%) View
AIG2_2 (PF13772) 2269 (16.8%) View
Total: 3 Total: 13516 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...