Summary
Tetraspannin-like
This clan includes the tetraspanin family which contains four transmembrane regions. The CD20 family also has four transmembrane regions, but its members are not considered true tetraspanins as they lack nearly all of the key functional tetraspanin residues [1].
This clan contains 6 families and the total number of domains in the clan is 30836. The clan was built by J Mistry and RD Finn.
Literature references
- Hemler ME;, J Cell Biol. 2001;155:1103-1107.: Specific tetraspanin functions. PUBMED:11756464 EPMC:11756464
Members
This clan contains the following 6 member families:
CD20 DUF2569 DUF4064 DUF4728 Mtp TetraspaninExternal database links
SCOP: | 48652 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
Tetraspanin (PF00335) | 23554 (76.4%) | View |
CD20 (PF04103) | 4706 (15.3%) | View |
Mtp (PF03821) | 1329 (4.3%) | View |
DUF4728 (PF15860) | 536 (1.7%) | View |
DUF2569 (PF10754) | 407 (1.3%) | View |
DUF4064 (PF13273) | 304 (1.0%) | View |
Total: 6 | Total: 30836 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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