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225  structures 8786  species 0  interactions 33196  sequences 266  architectures

Clan: SLOG (CL0349)


SMF/DprA-LOG (SLOG) Add an annotation

Members of the SLOG superfamily were shown in bacteria and plants to cleave modified AMPs to release the base as cytokinins, which function as growth-stimulating hormones in plants. Known family members such as DprA is a member of the recombination-mediator protein family, dedicated to natural bacterial transformation [1]. This clan includes members such as the classical LOG family which generates cytokinin-like molecules, the Smf/DprA family which binds single-stranded (ss)DNA and interacts with RecA during transformation and recombination and the molybdenum cofactor-binding (MoCoBD) family. The SLOG domain adopts a three-layered alpha/beta sandwich Rossmannoid fold with a characteristic substrate-binding loop rich in glycine and small residues in the standard location between strand-1 and helix-1. It is suggested that the SLOG superfamily is likely to encompass dual functions, with certain versions serving as (oligo)nucleotide sensors and others as enzymes that operate on nucleotides [2].

This clan contains 13 families and the total number of domains in the clan is 33196. The clan was built by A Bateman and S El-Gebali.

Literature references

  1. Mortier-Barriere I, Velten M, Dupaigne P, Mirouze N, Pietrement O, McGovern S, Fichant G, Martin B, Noirot P, Le Cam E, Polard P, Claverys JP; , Cell. 2007;130:824-836.: A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA. PUBMED:17803906 EPMC:17803906
  2. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;, Nucleic Acids Res. 2015;43:10633-10654.: Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling. PUBMED:26590262 EPMC:26590262


This clan contains the following 13 member families:

cpYpsA DNA_processg_A DUF3412 LD_cluster2 LD_cluster3 LDcluster4 LSDAT_euk LSDAT_prok Lysine_decarbox STALD TPALS YAcAr YpsA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lysine_decarbox (PF03641) 13945 (42.0%) View
DNA_processg_A (PF02481) 8574 (25.8%) View
LSDAT_euk (PF18139) 5551 (16.7%) View
YAcAr (PF10686) 1389 (4.2%) View
LDcluster4 (PF18306) 1199 (3.6%) View
YpsA (PF06908) 1037 (3.1%) View
DUF3412 (PF11892) 787 (2.4%) View
cpYpsA (PF12694) 307 (0.9%) View
STALD (PF18185) 134 (0.4%) View
LSDAT_prok (PF18171) 97 (0.3%) View
LD_cluster2 (PF18163) 93 (0.3%) View
LD_cluster3 (PF18180) 61 (0.2%) View
TPALS (PF18178) 22 (0.1%) View
Total: 13 Total: 33196 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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