Summary
CheC-like superfamily
The chemotactic response regulator superfamily are CheY-P phosphatases. Their structure is two intertwined alpha-beta-(X)-beta(2) motifs. This superfamily comprises two classes of proteins each shown to interact with the chemotaxis response regulator CheY: the FliM switch proteins and the CheC-type phosphatases [1]. FliM is a component of the flagellar switch found across the bacteria and is responsible for binding CheY-P and changing the rotational direction of the flagella. The N-terminal domain is CheC-like and the C-terminal shares the SpoA domain with FliN and FliY. The CheC family is broadly broken down into three phosphatase subfamilies: CheC, CheX, and FliY. All three have an active site consensus sequence of D/S-X(3)-E-X(2)-N-X(22)-P.
This clan contains 4 families and the total number of domains in the clan is 10123. The clan was built by A Bateman and TJ Tuff.
Literature references
- Muff TJ, Ordal GW;, Mol Microbiol. 2008;70:1054-1061.: The diverse CheC-type phosphatases: chemotaxis and beyond. PUBMED:18990184 EPMC:18990184
Members
This clan contains the following 4 member families:
CheC CheX DUF3334 FliMExternal database links
SCOP: | 103039 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
CheC (PF04509) | 4310 (42.6%) | View |
FliM (PF02154) | 3453 (34.1%) | View |
CheX (PF13690) | 2156 (21.3%) | View |
DUF3334 (PF11813) | 204 (2.0%) | View |
Total: 4 | Total: 10123 | Clan alignment |
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Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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