Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
213  structures 3299  species 0  interactions 12995  sequences 1281  architectures

Clan: H-int (CL0363)


Hedgehog/intein (Hint) superfamily Add an annotation

This superfamily includes Hedgehog C-terminal (Hog) autoprocessing domain and Intein (protein splicing domain) families.

This clan contains 8 families and the total number of domains in the clan is 12995. The clan was built by A Bateman.


This clan contains the following 8 member families:

AXH Hint Hint_2 Hom_end_hint Intein_splicing PT-HINT U6-snRNA_bdg Vint

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Hint_2 (PF13403) 3972 (30.6%) View
U6-snRNA_bdg (PF10596) 2020 (15.5%) View
Hint (PF01079) 1967 (15.1%) View
PT-HINT (PF07591) 1665 (12.8%) View
AXH (PF08517) 1431 (11.0%) View
Intein_splicing (PF14890) 1377 (10.6%) View
Vint (PF14623) 305 (2.3%) View
Hom_end_hint (PF05203) 258 (2.0%) View
Total: 8 Total: 12995 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...