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587  structures 1218  species 0  interactions 42618  sequences 378  architectures

Clan: Transporter (CL0375)


Transporter-like superfamily, four TM region Add an annotation

Members of this superfamily normally carry four transmembrane regions, which in many instances associate into hexameric structures. They are frequently involved in gap-junction formation between cells or in forming pores linking the cytosol with the extracellular space [1,2]. Some of them are transporters proteins, including members of the TCDB superfamilies 1.A.24 and 1.A.25.

This clan contains 14 families and the total number of domains in the clan is 42618. The clan was built by A Bateman.

Literature references

  1. Hua VB, Chang AB, Tchieu JH, Kumar NM, Nielsen PA, Saier MH Jr;, J Membr Biol. 2003;194:59-76.: Sequence and phylogenetic analyses of 4 TMS junctional proteins of animals: connexins, innexins, claudins and occludins. PUBMED:14502443 EPMC:14502443
  2. Abascal F, Zardoya R;, Bioessays. 2012;34:551-560.: LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication. PUBMED:22532330 EPMC:22532330


This clan contains the following 14 member families:

Amastin Atthog Claudin_2 Claudin_3 Clc-like Connexin Fig1 GSG-1 Innexin L_HMGIC_fpl Pannexin_like PMP22_Claudin SUR7 TMEM127

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PMP22_Claudin (PF00822) 13029 (30.6%) View
Connexin (PF00029) 7511 (17.6%) View
Claudin_2 (PF13903) 4802 (11.3%) View
Innexin (PF00876) 4788 (11.2%) View
SUR7 (PF06687) 4079 (9.6%) View
L_HMGIC_fpl (PF10242) 2826 (6.6%) View
Pannexin_like (PF12534) 1682 (3.9%) View
GSG-1 (PF07803) 1113 (2.6%) View
Fig1 (PF12351) 749 (1.8%) View
Atthog (PF18800) 520 (1.2%) View
Amastin (PF07344) 455 (1.1%) View
Clc-like (PF07062) 447 (1.0%) View
TMEM127 (PF20517) 374 (0.9%) View
Claudin_3 (PF06653) 243 (0.6%) View
Total: 14 Total: 42618 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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