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550  structures 8625  species 0  interactions 232036  sequences 5550  architectures

Clan: ANL (CL0378)


ANL superfamily Add an annotation

This superfamily consists of enzymes including luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely-related synthetases as well as a plant auxin-responsive promoter family. The name ANL derives from from three of the subfamilies - Acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes [1]. Members of this superfamily catalyse the initial adenylation of a carboxylate to form an acyl-AMP intermediate, followed by a second partial reaction, most commonly the formation of a thioester [1].

This clan contains 4 families and the total number of domains in the clan is 232036. The clan was built by A Bateman.

Literature references

  1. Gulick AM;, ACS Chem Biol. 2009;4:811-827.: Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase. PUBMED:19610673 EPMC:19610673


This clan contains the following 4 member families:

ACAS_N AMP-binding GH3 LuxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AMP-binding (PF00501) 206751 (89.1%) View
ACAS_N (PF16177) 16566 (7.1%) View
GH3 (PF03321) 7466 (3.2%) View
LuxE (PF04443) 1253 (0.5%) View
Total: 4 Total: 232036 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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