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29  structures 66  species 0  interactions 124  sequences 19  architectures

Clan: Bacteriocin_TLN (CL0446)


Translocation domain of colicin-like bacteriocins Add an annotation

A number of different bacterial species produce bacteriocins to kill competitor species, and the colicin class is a group of complex three-domain structures. The receptor-binding domain recognises and binds to specific cell surface receptors on the target cells; the N-terminal translocation domain interacts with cell membrane proteins to gain access to the cell interior; the C-terminal domain specifies a killing activity, such as pore formation or nuclease activity. This superfamily is a collection of the translocating domains.

This clan contains 2 families and the total number of domains in the clan is 124. The clan was built by P Coggill.

Literature references

  1. Soelaiman S, Jakes K, Wu N, Li C, Shoham M;, Mol Cell. 2001;8:1053-1062.: Crystal structure of colicin E3: implications for cell entry and ribosome inactivation. PUBMED:11741540 EPMC:11741540
  2. Chavan M, Rafi H, Wertz J, Goldstone C, Riley MA;, J Mol Evol. 2005;60:546-556.: Phage associated bacteriocins reveal a novel mechanism for bacteriocin diversification in Klebsiella. PUBMED:15883889 EPMC:15883889


This clan contains the following 2 member families:

Cloacin Pyocin_S

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pyocin_S (PF06958) 117 (94.4%) View
Cloacin (PF03515) 7 (5.6%) View
Total: 2 Total: 124 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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