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24  structures 1424  species 0  interactions 2840  sequences 88  architectures

Clan: TPA-repeat (CL0462)


Transcription elongation factor C-terminal nonapeptide repeat Add an annotation

This superfamily includes several families of this nonapeptide repeat, that carries a characteristic TPA motif. The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II.

This clan contains 2 families and the total number of domains in the clan is 2840. The clan was built by P Coggill.

Literature references

  1. Schwer B, Schneider S, Pei Y, Aronova A, Shuman S;, RNA. 2009; [Epub ahead of print]: Characterization of the Schizosaccharomyces pombe Spt5-Spt4 complex. PUBMED:19460865 EPMC:19460865


This clan contains the following 2 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SF3b1 (PF08920) 1798 (63.3%) View
CTD (PF12815) 1042 (36.7%) View
Total: 2 Total: 2840 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...