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468  structures 8882  species 0  interactions 66392  sequences 570  architectures

Clan: PreATP-grasp (CL0483)


Probable substrate-binding preceding ATP-grasp domain Add an annotation

This superfamily is characterised by bein g the copies of the domain that precedes the ATP-grasp domain common to all superfamily members, and it can contain a substrate-binding function.

This clan contains 11 families and the total number of domains in the clan is 66392. The clan was built by P Coggill.

Literature references

  1. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH;, EMBO J. 2006;25:5970-5982.: Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. PUBMED:17124497 EPMC:17124497


This clan contains the following 11 member families:

Biotin_carb_N Dala_Dala_lig_N DUF1246 GARS_N GSH-S_N GSH_synth_ATP GSH_synthase Ins134_P3_kin_N PPIP5K2_N Rimk_N Synapsin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Biotin_carb_N (PF00289) 29026 (43.7%) View
GARS_N (PF02844) 9648 (14.5%) View
Dala_Dala_lig_N (PF01820) 9608 (14.5%) View
PPIP5K2_N (PF18086) 4207 (6.3%) View
GSH-S_N (PF02951) 3295 (5.0%) View
GSH_synth_ATP (PF03917) 2672 (4.0%) View
GSH_synthase (PF03199) 2321 (3.5%) View
Rimk_N (PF18030) 2262 (3.4%) View
Ins134_P3_kin_N (PF17927) 1756 (2.6%) View
Synapsin (PF02078) 1362 (2.1%) View
DUF1246 (PF06849) 235 (0.4%) View
Total: 11 Total: 66392 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...