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38  structures 4219  species 0  interactions 20121  sequences 254  architectures

Clan: MBOAT-like (CL0517)


Membrane-bound O-acyltransferase,MBOAT,superfamily Add an annotation

This is a large superfamily of different enzymes. All biochemically characterised members of the superfamily encode enzymes that transfer organic acids, typically fatty acids, onto hydroxyl groups of membrane-embedded targets.

This clan contains 2 families and the total number of domains in the clan is 20121. The clan was built by P Coggill.

Literature references

  1. Stahl U, Stalberg K, Stymne S, Ronne H;, FEBS Lett. 2008;582:305-309.: A family of eukaryotic lysophospholipid acyltransferases with broad specificity. PUBMED:18154737 EPMC:18154737
  2. Hofmann K; , Trends Biochem Sci 2000;25:111-112.: A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. PUBMED:10694878 EPMC:10694878


This clan contains the following 2 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MBOAT (PF03062) 16184 (80.4%) View
MBOAT_2 (PF13813) 3937 (19.6%) View
Total: 2 Total: 20121 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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