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126  structures 1595  species 0  interactions 86629  sequences 1693  architectures

Clan: CCCH_zf (CL0537)


CCCH-zinc finger Add an annotation

This superfamily is characterised by families of proteins with several Cys3His zinc-binding domains in tandem.

This clan contains 11 families and the total number of domains in the clan is 86629. The clan was built by P Coggill.


This clan contains the following 11 member families:

Nab2p_Zf1 Torus zf-CCCH zf-CCCH_2 zf-CCCH_3 zf-CCCH_4 zf-CCCH_6 zf-CCCH_7 zf-CCCH_8 zf_CCCH_4 zf_CCCH_5

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-CCCH (PF00642) 49585 (57.2%) View
zf-CCCH_2 (PF14608) 23330 (26.9%) View
zf-CCCH_4 (PF18044) 7849 (9.1%) View
zf-CCCH_3 (PF15663) 1617 (1.9%) View
Torus (PF16131) 1602 (1.8%) View
zf_CCCH_5 (PF18384) 1152 (1.3%) View
zf_CCCH_4 (PF18345) 1081 (1.2%) View
zf-CCCH_6 (PF18585) 255 (0.3%) View
zf-CCCH_8 (PF18633) 127 (0.1%) View
Nab2p_Zf1 (PF18260) 28 (0.0%) View
zf-CCCH_7 (PF18586) 3 (0.0%) View
Total: 11 Total: 86629 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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