Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
864  structures 1709  species 0  interactions 63332  sequences 1180  architectures

Clan: SH2-like (CL0541)


SH2, phosphotyrosine-recognition domain superfamily Add an annotation

This superfamily is characterised by proteins with the SH2-like fold. The proesence of this domain guides signal-transduction towards the phosphorylated tyrosine residues on its interacting protein-partner.

This clan contains 4 families and the total number of domains in the clan is 63332. The clan was built by P Coggill.

Literature references

  1. Tong L, Warren TC, King J, Betageri R, Rose J, Jakes S;, J Mol Biol. 1996;256:601-610.: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. PUBMED:8604142 EPMC:8604142


This clan contains the following 4 member families:

Cbl_N3 MelC1 SH2 SH2_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SH2 (PF00017) 59304 (93.6%) View
SH2_2 (PF14633) 2057 (3.2%) View
Cbl_N3 (PF02762) 1614 (2.5%) View
MelC1 (PF06236) 357 (0.6%) View
Total: 4 Total: 63332 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...