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430  structures 7350  species 0  interactions 96416  sequences 495  architectures

Clan: AcylCoA_ox_dh_N (CL0544)


Acyl-coenzyme A oxidase/dehydrogenase N-terminal Add an annotation

Acyl-CoA dehydrogenases and acyl-coenzyme A oxidases consist of three domains. An N-terminal all alpha domain, a beta-barrel middle domain and a C-terminal catalytic domain [1-2].

This clan contains 3 families and the total number of domains in the clan is 96416. The clan was built by R Eberhardt.

Literature references

  1. Kim JJ, Wang M, Paschke R; , Proc Natl Acad Sci U S A 1993;90:7523-7527.: Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. PUBMED:8356049 EPMC:8356049
  2. Pedersen L, Henriksen A;, J Mol Biol. 2005;345:487-500.: Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism. PUBMED:15581893 EPMC:15581893


This clan contains the following 3 member families:

Acyl-CoA_dh_N Acyl-CoA_ox_N AidB_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Acyl-CoA_dh_N (PF02771) 89239 (92.6%) View
AidB_N (PF18158) 3748 (3.9%) View
Acyl-CoA_ox_N (PF14749) 3429 (3.6%) View
Total: 3 Total: 96416 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...