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808  structures 1401  species 0  interactions 6914  sequences 99  architectures

Clan: BCLiA (CL0551)


Bcl-2 inhibitors of programmed cell death Add an annotation

This superfamily is characterised by families of proteins that inhibit apoptosis, They are regulated by all BH3-only proteins to promote apoptosis.

This clan contains 6 families and the total number of domains in the clan is 6914. The clan was built by P Coggill.

Literature references

  1. Korsmeyer SJ;, Cancer Res. 1999;59:1693.: BCL-2 gene family and the regulation of programmed cell death. PUBMED:10197582 EPMC:10197582
  2. Youle RJ, Strasser A;, Nat Rev Mol Cell Biol. 2008;9:47-59.: The BCL-2 protein family: opposing activities that mediate cell death. PUBMED:18097445 EPMC:18097445


This clan contains the following 6 member families:

ATG14 Bcl-2 Bcl-2_3 BID Poxv_Bcl-2-like VPS38

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Bcl-2 (PF00452) 3678 (53.2%) View
ATG14 (PF10186) 2654 (38.4%) View
BID (PF06393) 323 (4.7%) View
Poxv_Bcl-2-like (PF06227) 136 (2.0%) View
VPS38 (PF17649) 120 (1.7%) View
Bcl-2_3 (PF15286) 3 (0.0%) View
Total: 6 Total: 6914 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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