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49  structures 1538  species 0  interactions 12436  sequences 246  architectures

Clan: LisH (CL0561)


LisH-like Add an annotation

Members of this clan include the LisH dimerisation/tetramerisation domains and the FOP N terminal dimerisation domain.

This clan contains 4 families and the total number of domains in the clan is 12436. The clan was built by R Eberhardt.

Literature references

  1. Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA; , J Mol Biol. 2006;359:863-875.: Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. PUBMED:16690081 EPMC:16690081
  2. Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW;, Nat Struct Mol Biol. 2011;18:177-184.: Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. PUBMED:21240272 EPMC:21240272


This clan contains the following 4 member families:

FOP_dimer LisH LisH_2 LisH_TPL

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LisH (PF08513) 7906 (63.6%) View
LisH_TPL (PF17814) 2365 (19.0%) View
FOP_dimer (PF09398) 1262 (10.1%) View
LisH_2 (PF16045) 903 (7.3%) View
Total: 4 Total: 12436 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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