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258  structures 3207  species 0  interactions 6357  sequences 43  architectures

Clan: Phage_TTPs (CL0569)


Phage tail tube proteins superfamily Add an annotation

This superfamily represents families of phage tail tube proteins TTPs. Most bacteriophages possess a long tail that is either non-contractile as in the Siphoviridae family or contractile as in the Myoviridae family. These multi-component structures are assembled in regulated pathways that commence with the formation of the tail tip. Tail tip complexes, also referred to as baseplates in some phages, vary considerably in size and protein composition, but all probably serve as the initiator of tail tube protein polymerisation. The tube protein in each case is a long tubular strucutre through which the viral DNA passes during infection. The tube is created by polymerisation of the tube single tube protein. Contractile tails include a central tail tube protein (TTP) that is surrounded by a tail sheath protein (TSP). On infection, the tail sheath contracts and the TTP penetrates the outer cell membrane and cell wall [1,2,3].

This clan contains 9 families and the total number of domains in the clan is 6357. The clan was built by P Coggill.

Literature references

  1. Pell LG, Kanelis V, Donaldson LW, Howell PL, Davidson AR;, Proc Natl Acad Sci U S A. 2009;106:4160-4165.: The phage lambda major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system. PUBMED:19251647 EPMC:19251647
  2. Tam W, Pell LG, Bona D, Tsai A, Dai XX, Edwards AM, Hendrix RW, Maxwell KL, Davidson AR;, J Mol Biol. 2013;425:2450-2462.: Tail tip proteins related to bacteriophage lambda gpL coordinate an iron-sulfur cluster. PUBMED:23542343 EPMC:23542343
  3. Pell LG, Cumby N, Clark TE, Tuite A, Battaile KP, Edwards AM, Chirgadze NY, Davidson AR, Maxwell KL;, J Mol Biol. 2013;425:2436-2449.: A conserved spiral structure for highly diverged phage tail assembly chaperones. PUBMED:23542344 EPMC:23542344


This clan contains the following 9 member families:

L_lac_phage_MSP Phage_T4_gp19 Phage_tail_2 Phage_tail_3 Phage_TTP_1 Phage_TTP_11 Phage_TTP_12 Phage_TTP_13 Phage_tube

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Phage_T4_gp19 (PF06841) 2994 (47.1%) View
Phage_tail_2 (PF06199) 1433 (22.5%) View
Phage_tube (PF04985) 824 (13.0%) View
Phage_TTP_1 (PF04630) 362 (5.7%) View
Phage_tail_3 (PF08813) 281 (4.4%) View
Phage_TTP_12 (PF16461) 280 (4.4%) View
L_lac_phage_MSP (PF06488) 87 (1.4%) View
Phage_TTP_11 (PF16460) 58 (0.9%) View
Phage_TTP_13 (PF16463) 38 (0.6%) View
Total: 9 Total: 6357 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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