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33  structures 578  species 0  interactions 701  sequences 29  architectures

Clan: OML_zippers (CL0590)


Major outer membrane lipoprotein zipper superfamily Add an annotation

This is a superfamily of short outer membrane lipoporteins that are coiled-coils of alpha-helices. The families included are both leucine and alanine zippers. A zipper motif is a heptad or seven-residue repeat, represented by X..X...X..X...X..X...X..X...X..X, etc, where the X is hydrophobic residue, usually a leucine or alanine, and the intermediate residues are largely polar or hydrophilic; that is, the responsible residues occur at positions 1 and 4 in the heptad. Monomers combine together into dimers and higher order structures. Coiled-coil motifs are ubiquitous mediators of specific protein-protein interactions, in this case outer membrane 'tubes', by forming interlocking hydrophobic seams between the alpha-helical chains [1].

This clan contains 3 families and the total number of domains in the clan is 701. The clan was built by P Coggill.

Literature references

  1. Abarca F, Gutierrez-Maldonado SE, Parada P, Martinez P, Maass A, Perez-Acle T;, PeerJ. 2014;2:e457.: Insights on the structure and stability of Licanantase: a trimeric acid-stable coiled-coil lipoprotein from Acidithiobacillus thiooxidans. PUBMED:25165619 EPMC:25165619


This clan contains the following 3 member families:

Alanine_zipper FadA LPP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Alanine_zipper (PF11839) 395 (56.3%) View
LPP (PF04728) 274 (39.1%) View
FadA (PF09403) 32 (4.6%) View
Total: 3 Total: 701 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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