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75  structures 2273  species 0  interactions 129323  sequences 4659  architectures

Clan: beta_Roll (CL0592)


beta-strand roll of R-module, superfamily Add an annotation

This superfamily is characterised by families of a short nonarepeat unit. The beta-roll is made up of a super-helix of beta-strand-turns of two short strands each, and the loops are stabilised by Ca2+ ions. The region of a protein with this beta-roll is often termed the R-module, and it can frequently be found in metalloproteases of the serralysin type and in epimerases [1]. The nonarepeat is also found multiple times in haemolysins, where the structure is again stabilised by binding Ca2+ ions.

This clan contains 2 families and the total number of domains in the clan is 129323. The clan was built by P Coggill.

Literature references

  1. Aachmann FL, Svanem BI, Guntert P, Petersen SB, Valla S, Wimmer R;, J Biol Chem. 2006;281:7350-7356.: NMR structure of the R-module: a parallel beta-roll subunit from an Azotobacter vinelandii mannuronan C-5 epimerase. PUBMED:16407237 EPMC:16407237


This clan contains the following 2 member families:

HemolysinCabind Peptidase_M10_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HemolysinCabind (PF00353) 127693 (98.7%) View
Peptidase_M10_C (PF08548) 1630 (1.3%) View
Total: 2 Total: 129323 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...