Summary
SRP alu RNA binding heterodimer, SRP9/14 superfamily
This superfamily represents both the 9 kDa SRP9 and the 14 kDa SRP14 components. Both SRP9 and SRP14 have the same (beta)-alpha-beta(3)-alpha fold. The heterodimer has pseudo two-fold symmetry and is saddle-like, consisting of a curved six-stranded beta-sheet that has four helices packed on the convex side and an exposed concave surface lined with positively charged residues. The SRP9/SRP14 heterodimer is essential for SRP RNA binding, mediating the pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP.
This clan contains 2 families and the total number of domains in the clan is 3082. The clan was built by A Bateman.
Literature references
- Hsu K, Chang DY, Maraia RJ; , J Biol Chem 1995;270:10179-10186.: Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. PUBMED:7730321 EPMC:7730321
Members
This clan contains the following 2 member families:
SRP14 SRP9-21External database links
SCOP: | 54762 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
SRP14 (PF02290) | 1666 (54.1%) | View |
SRP9-21 (PF05486) | 1416 (45.9%) | View |
Total: 2 | Total: 3082 | Clan alignment |
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Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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