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230  structures 1651  species 0  interactions 7591  sequences 140  architectures

Clan: eIF4e (CL0625)


eIF4e-like superfamily Add an annotation

This superfamily includes eIF4e as well as the family that includes BLES03 [1].

This clan contains 3 families and the total number of domains in the clan is 7591. The clan was built by A Bateman.

Literature references

  1. Bitto E, Bingman CA, Robinson H, Allard ST, Wesenberg GE, Phillips GN Jr;, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:812-817.: The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. PUBMED:16511166 EPMC:16511166


This clan contains the following 3 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
IF4E (PF01652) 6675 (87.9%) View
DUF1917 (PF08939) 892 (11.8%) View
VRP3 (PF03536) 24 (0.3%) View
Total: 3 Total: 7591 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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