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45  structures 2523  species 0  interactions 6223  sequences 102  architectures

Clan: Pre-PUA (CL0668)


Pre-PUA superfamily Add an annotation

This superfamily is named after the fact that this domain is found to the N-terminus of PUA domains in some proteins. The domains in this superfamily have a cystatin like fold.

This clan contains 5 families and the total number of domains in the clan is 6223. The clan was built by A Bateman.


This clan contains the following 5 member families:

DUF1947 Pre-PUA RsmF_methylt_CI TGT_C2 UPF0113_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pre-PUA (PF17832) 3104 (49.9%) View
UPF0113_N (PF17833) 1749 (28.1%) View
RsmF_methylt_CI (PF17126) 882 (14.2%) View
TGT_C2 (PF14810) 396 (6.4%) View
DUF1947 (PF09183) 92 (1.5%) View
Total: 5 Total: 6223 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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