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14  structures 2753  species 0  interactions 9228  sequences 235  architectures

Clan: GYF (CL0673)


GYF domain Add an annotation

GYF domains are small, versatile adaptor domains that recognize proline-rich sequences (PRS). Mutational and structural analysis has shown the conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF to be the site of interaction with proline-rich peptides. In contrast, composition and length of the C-terminal half of GYF domains are not conserved. GYF domains bind to many different PRS that converge on a minimal consensus sequence [1].

This clan contains 2 families and the total number of domains in the clan is 9228. The clan was built by S El-Gebali.

Literature references

  1. Kofler MM, Freund C;, FEBS J. 2006;273:245-256.: The GYF domain. PUBMED:16403013 EPMC:16403013


This clan contains the following 2 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GYF (PF02213) 5422 (58.8%) View
GYF_2 (PF14237) 3806 (41.2%) View
Total: 2 Total: 9228 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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