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0  structures 859  species 0  interactions 1063  sequences 11  architectures

Clan: MICOS (CL0683)


Mitochondrial contact site complex Add an annotation

Mitofilin proteins are crucial organizers of mitochondrial architecture. They are located in the inner mitochondrial membrane and interact with several protein complexes of the outer membrane, thereby generating contact sites between the two membrane systems of mitochondria. They are part of hetero-oligomeric protein complexes that have been termed the mitochondrial inner membrane organizing system (MINOS), alternatively, mitochondrial organizing structure (MitOS) or mitochondrial contact site (MICOS) complex [1]. MICOS interacts with components of the sorting and assembly machinery (SAM) complex of the outer membrane to form the mitochondrial intermembrane space bridging (MIB) complex [2].

This clan contains 2 families and the total number of domains in the clan is 1063. The clan was built by S El-Gebali.

Literature references

  1. Zerbes RM, van der Klei IJ, Veenhuis M, Pfanner N, van der Laan M, Bohnert M;, Biol Chem. 2012;393:1247-1261.: Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. PUBMED:23109542 EPMC:23109542
  2. Huynen MA, Muhlmeister M, Gotthardt K, Guerrero-Castillo S, Brandt U;, Biochim Biophys Acta. 2016;1863:91-101.: Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. PUBMED:26477565 EPMC:26477565


This clan contains the following 2 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
QIL1 (PF15884) 550 (51.7%) View
AIM5 (PF17050) 513 (48.3%) View
Total: 2 Total: 1063 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...