Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
169  structures 1118  species 0  interactions 2459  sequences 139  architectures

Clan: EndoU (CL0695)


EndoU-like endoribonuclease superfamily Add an annotation

This superfamily includes U-specific metal dependent enzymes that releases products with 2'-3' cyclic phosphate termini. XendoU is broadly conserved among eukaryotes, and it is a genetic marker of nidoviruses, including the severe acute respiratory syndrome coronavirus, where it is essential for replication and transcription [1].

This clan contains 3 families and the total number of domains in the clan is 2459. The clan was built by A Bateman.

Literature references

  1. Renzi F, Caffarelli E, Laneve P, Bozzoni I, Brunori M, Vallone B; , Proc Natl Acad Sci U S A. 2006;103:12365-12370.: The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication. PUBMED:16895992 EPMC:16895992


This clan contains the following 3 member families:

CoV_NSP15_C EndoU_bacteria XendoU

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
XendoU (PF09412) 1907 (77.6%) View
EndoU_bacteria (PF14436) 447 (18.2%) View
CoV_NSP15_C (PF19215) 105 (4.3%) View
Total: 3 Total: 2459 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...