Summary
EAD1-like clan
Effector-associated domains (EADs) are predicted to function as adaptor domains mediating protein-protein interactions. The EADs show a characteristic architectural pattern. One copy is always fused, typically to the N- or C-terminus, of a core component of a biological conflict system; examples include VMAP, iSTAND, or GAP1. Further copies of the same EAD are fused to either effector or signal-transducing domains, or additional EADs. EAD pairs are frequently observed together on the genome in conserved gene neighborhoods, but can also be severed from such neighborhoods and located in distant regions, indicating the EAD-EAD coupling approximates the advantages of collinear transcription. This superfamily includes several families that are related to the EAD1 family.
This clan contains 6 families and the total number of domains in the clan is 873. The clan was built by L Aravind and LM Iyer.
Literature references
- Kaur G, Burroughs AM, Iyer LM, Aravind L;, Elife. 2020; [Epub ahead of print]: Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity. PUBMED:32101166 EPMC:32101166
Members
This clan contains the following 6 member families:
EAD1 EAD10 EAD2 EAD6 EAD7 EAD8Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
Loading domain graphics...
Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
EAD1 (PF19955) | 375 (43.0%) | View |
EAD2 (PF19956) | 333 (38.1%) | View |
EAD8 (PF19961) | 62 (7.1%) | View |
EAD10 (PF19954) | 60 (6.9%) | View |
EAD7 (PF19960) | 41 (4.7%) | View |
EAD6 (PF19958) | 2 (0.2%) | View |
Total: 6 | Total: 873 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
Loading...