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20  structures 1394  species 0  interactions 12856  sequences 240  architectures

Clan: UIM (CL0702)


Ubiquitin interacting motif Add an annotation

This clan includes families containing the ubiquitin interacting motif (UIM) involved in the recognition of polyUb chains which forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface with Ubl. Families in this clan have one or more UIM motifs, providing different binding properties or targets and a wide range of functions.

This clan contains 2 families and the total number of domains in the clan is 12856. The clan was built by S Chuguransky and A Bateman.

Literature references

  1. Hiyama H, Yokoi M, Masutani C, Sugasawa K, Maekawa T, Tanaka K, Hoeijmakers JH, Hanaoka F; , J Biol Chem 1999;274:28019-28025.: Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome. PUBMED:10488153 EPMC:10488153
  2. Anamika, Markin CJ, Rout MK, Spyracopoulos L;, J Biol Chem. 2014;289:12852-12862.: Molecular basis for impaired DNA damage response function associated with the RAP80 DeltaE81 defect. PUBMED:24627472 EPMC:24627472


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UIM (PF02809) 12520 (97.4%) View
RAP80_UIM (PF18282) 336 (2.6%) View
Total: 2 Total: 12856 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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