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196  structures 1437  species 0  interactions 22659  sequences 309  architectures

Clan: VBS-like (CL0705)


VBS-like four-helical bundle superfamily Add an annotation

This superfamily groups families with the conserved four or five-helix up-and-down bundle structure which is conserved and typical of focal adhesion targeting (FAT) domains. This structure is responsible for dimerisation, being also present in transcriptional regulators in which it is important for their dynamic conformational equilibrium to control the target specificity.

This clan contains 9 families and the total number of domains in the clan is 22659. The clan was built by S Chuguransky and A Bateman.

Literature references

  1. Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC;, FEBS Lett. 2010; [Epub ahead of print]: The domain structure of talin: Residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site. PUBMED:20399778 EPMC:20399778
  2. McCann RO, Craig SW; , Proc Natl Acad Sci U S A 1997;94:5679-5684.: The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals. PUBMED:9159132 EPMC:9159132
  3. Tikhmyanova N, Little JL, Golemis EA;, Cell Mol Life Sci. 2010;67:1025-1048.: CAS proteins in normal and pathological cell growth control. PUBMED:19937461 EPMC:19937461
  4. Zhang C, Miller DJ, Guibao CD, Donato DM, Hanks SK, Zheng JJ., J Biol Chem. 2017 Nov 3;292(44):18281-18289.: Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin. PUBMED:28860193 EPMC:28860193
  5. Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi S, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O;, EMBO J. 2012 May 30; 31(11): 2541–2552.: Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. PUBMED:22453338 EPMC:22453338


This clan contains the following 9 member families:

CAS_C DUF1241 GCIP HIP1_clath_bdg I_LWEQ Serendipity_A Talin_middle VBS Vinculin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Vinculin (PF01044) 7946 (35.1%) View
I_LWEQ (PF01608) 4677 (20.6%) View
VBS (PF08913) 2530 (11.2%) View
CAS_C (PF12026) 2005 (8.8%) View
Talin_middle (PF09141) 1741 (7.7%) View
GCIP (PF13324) 1699 (7.5%) View
HIP1_clath_bdg (PF16515) 1145 (5.1%) View
DUF1241 (PF06840) 806 (3.6%) View
Serendipity_A (PF05482) 110 (0.5%) View
Total: 9 Total: 22659 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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