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13  structures 1615  species 0  interactions 3498  sequences 64  architectures

Clan: EMC6 (CL0706)


EMC6 Add an annotation

The prototype member of this clan is the ER membrane protein complex subunit 6 (EMC6), a member of the ER membrane protein complex (EMC), a conserved co- and post-translational insertase at the endoplasmic reticulum. EMC6 forms a hydrophilic vestibule with EMC3 subunit which provides a methionine-rich cytosolic loop required for substrate insertion. This clan also includes: Get2 from yeast, Get2-like (CAML) from mammals or EMC6-like from Archaea. They all contain three transmembrane domains.

This clan contains 4 families and the total number of domains in the clan is 3498. The clan was built by A LewisA Bateman and S Chuguransky.

Literature references

  1. Yamamoto Y, Sakisaka T;, J Biochem. 2015;157:419-429.: The emerging role of calcium-modulating cyclophilin ligand in posttranslational insertion of tail-anchored proteins into the endoplasmic reticulum membrane. PUBMED:25869254 EPMC:25869254
  2. O'Donnell JP, Phillips BP, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, Keenan RJ, Miller EA, Hegde RS;, Elife. 2020; [Epub ahead of print]: The architecture of EMC reveals a path for membrane protein insertion. PUBMED:32459176 EPMC:32459176
  3. Pleiner T, Tomaleri GP, Januszyk K, Inglis AJ, Hazu M, Voorhees RM;, Science. 2020;369:433-436.: Structural basis for membrane insertion by the human ER membrane protein complex. PUBMED:32439656 EPMC:32439656


This clan contains the following 4 member families:

EMC6 EMC6_arch GET2 Get2_like

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EMC6 (PF07019) 2277 (65.1%) View
GET2 (PF08690) 665 (19.0%) View
Get2_like (PF14963) 379 (10.8%) View
EMC6_arch (PF19094) 177 (5.1%) View
Total: 4 Total: 3498 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...