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245  structures 5848  species 0  interactions 18745  sequences 74  architectures

Clan: COX1-like (CL0714)

Summary

Cytochrome c oxidase subunit I-like superfamily Add an annotation

This superfamily includes the catalytic subunit of all haem-copper respiratory oxidases, which is equivalent to mammalian cytochrome c oxidase subunit I (COX1). The bimetallic centre (formed by a high-spin haem and copper B) and the low-spin haem, ligated to six conserved histidine residues near the outer side of four transmembrane spans within COXI is common to all members [1,2]. Bacterial nitric oxide reductases (NORs), involved in microbial denitrification, are divided in cytochrome c–dependent NOR (cNOR) and quinol-dependent NOR (qNOR), based on their electron donor [2].

This clan contains 2 families and the total number of domains in the clan is 18745. The clan was built by S Chuguransky.

Literature references

  1. Castresana J, Lubben M, Saraste M, Higgins DG;, EMBO J. 1994;13:2516-2525.: Evolution of cytochrome oxidase, an enzyme older than atmospheric oxygen. PUBMED:8013452 EPMC:8013452
  2. Gopalasingam CC, Johnson RM, Chiduza GN, Tosha T, Yamamoto M, Shiro Y, Antonyuk SV, Muench SP, Hasnain SS;, Sci Adv. 2019;5:eaax1803.: Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy. PUBMED:31489376 EPMC:31489376

Members

This clan contains the following 2 member families:

COX1 NnrS

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
COX1 (PF00115) 16920 (90.3%) View
NnrS (PF05940) 1825 (9.7%) View
Total: 2 Total: 18745 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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