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1  structure 741  species 0  interactions 2782  sequences 40  architectures

Clan: Perilipin_sf (CL0718)


Perilipin superfamily Add an annotation

This superfamily is represented by the C-terminal domain of Mannose-6-phosphate receptor binding protein 1 (TIP47, also known as perilipin-3) whose structure has a capital "L" shape in which the foot consists of a compact alpha/beta domain and the leg comprises an elongated four-helix bundle [1]. TIP47 shares sequence similarity with perilipin and ADRP (adipose differentiation-related protein), which together form the PAT (perilipin/APRP/TIP47) family of proteins [1].

This clan contains 2 families and the total number of domains in the clan is 2782. The clan was built by S Chuguransky.

Literature references

  1. Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH;, Structure. 2004;12:1199-1207.: Structure of a lipid droplet protein; the PAT family member TIP47. PUBMED:15242596 EPMC:15242596


This clan contains the following 2 member families:

Perilipin Perilipin_2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Perilipin (PF03036) 2430 (87.3%) View
Perilipin_2 (PF17316) 352 (12.7%) View
Total: 2 Total: 2782 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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