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1  structure 741  species 0  interactions 2782  sequences 40  architectures

Clan: Perilipin_sf (CL0718)

Summary

Perilipin superfamily Add an annotation

This superfamily is represented by the C-terminal domain of Mannose-6-phosphate receptor binding protein 1 (TIP47, also known as perilipin-3) whose structure has a capital "L" shape in which the foot consists of a compact alpha/beta domain and the leg comprises an elongated four-helix bundle [1]. TIP47 shares sequence similarity with perilipin and ADRP (adipose differentiation-related protein), which together form the PAT (perilipin/APRP/TIP47) family of proteins [1].

This clan contains 2 families and the total number of domains in the clan is 2782. The clan was built by S Chuguransky.

Literature references

  1. Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH;, Structure. 2004;12:1199-1207.: Structure of a lipid droplet protein; the PAT family member TIP47. PUBMED:15242596 EPMC:15242596

Members

This clan contains the following 2 member families:

Perilipin Perilipin_2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Perilipin (PF03036) 2430 (87.3%) View
Perilipin_2 (PF17316) 352 (12.7%) View
Total: 2 Total: 2782 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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