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13  structures 328  species 0  interactions 717  sequences 20  architectures

Clan: Lag3_N (CL0720)


Lag3 N-terminal region superfamily Add an annotation

Members of this superfamily, such as the N-terminal domain of Lag3 and MamL-1, adopt an elongated kinked helix which is the minimal region required for protein interactions to form complexes [1,2,3].

This clan contains 3 families and the total number of domains in the clan is 717. The clan was built by A Bateman and S Chuguransky.

Literature references

  1. Hoh F, Uzest M, Drucker M, Plisson-Chastang C, Bron P, Blanc S, Dumas C;, J Virol. 2010;84:4706-4713.: Structural insights into the molecular mechanisms of cauliflower mosaic virus transmission by its insect vector. PUBMED:20181714 EPMC:20181714
  2. Nam Y, Sliz P, Song L, Aster JC, Blacklow SC; , Cell. 2006;124:973-983.: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. PUBMED:16530044 EPMC:16530044
  3. Wilson JJ, Kovall RA;, Cell. 2006;124:985-996.: Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. PUBMED:16530045 EPMC:16530045


This clan contains the following 3 member families:

Activator_LAG-3 Cauli_DNA-bind MamL-1

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MamL-1 (PF09596) 649 (90.5%) View
Activator_LAG-3 (PF11498) 53 (7.4%) View
Cauli_DNA-bind (PF03310) 15 (2.1%) View
Total: 3 Total: 717 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...