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10  structures 394  species 0  interactions 2978  sequences 39  architectures

Clan: LAMP (CL0721)


LAMP superfamily Add an annotation

This superfamily includes LAMP and LAMP-like members which are structurally similar. The luminal domain has a beta-prim structure composed of 10 beta-strands, in which beta-4-8 form a planar beta-sheet and beta-1-3, 9 and 10 assembly into a bent beta-sheet opposing the planar beta-sheet [1].

This clan contains 2 families and the total number of domains in the clan is 2978. The clan was built by S Chuguransky.

Literature references

  1. Wang L, Wu D, Robinson CV, Wu H, Fu TM;, Mol Cell. 2020;80:501-511.: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. PUBMED:33065002 EPMC:33065002


This clan contains the following 2 member families:

Lamp VAS1_LD

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lamp (PF01299) 2011 (67.5%) View
VAS1_LD (PF05827) 967 (32.5%) View
Total: 2 Total: 2978 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...