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2052  structures 7241  species 0  interactions 118686  sequences 1108  architectures

Clan: CU_oxidase (CL0026)


Multicopper oxidase-like domain Add an annotation

Many of the proteins in this family contain multiple similar copies of this plastocyanin-like domain.

This clan contains 15 families and the total number of domains in the clan is 118686. The clan was built by DJ Studholme and RD Finn.

Literature references

  1. Messerschmidt A, Huber R; , Eur J Biochem 1990;187:341-352.: The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships. PUBMED:2404764 EPMC:2404764
  2. Messerschmidt A, Ladenstein R, Huber R, Bolognesi M, Avigliano L, Petruzzelli R, Rossi A, Finazzi-Agro A; , J Mol Biol 1992;224:179-205.: Refined crystal structure of ascorbate oxidase at 1.9 A resolution. PUBMED:1548698 EPMC:1548698
  3. Page CC, Moser CC, Chen X, Dutton PL; , Nature 1999;402:47-52.: Natural engineering principles of electron tunnelling in biological oxidation-reduction. PUBMED:10573417 EPMC:10573417
  4. Grossmann JG, Ingledew WJ, Harvey I, Strange RW, Hasnain SS; , Biochemistry 1995;34:8406-8414.: X-ray absorption studies and homology modeling define the structural features that specify the nature of the copper site in rusticyanin. PUBMED:7599131 EPMC:7599131


This clan contains the following 15 member families:

Copper-bind COX2 COX_ARM Cu-oxidase Cu-oxidase_2 Cu-oxidase_3 Cu_bind_like Cupredoxin_1 CzcE DP-EP Ephrin hGDE_N PAD_N PixA SoxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cu-oxidase_3 (PF07732) 31736 (26.7%) View
Cu-oxidase_2 (PF07731) 28607 (24.1%) View
Cu-oxidase (PF00394) 22029 (18.6%) View
Cu_bind_like (PF02298) 9940 (8.4%) View
COX2 (PF00116) 9671 (8.1%) View
Copper-bind (PF00127) 4921 (4.1%) View
Cupredoxin_1 (PF13473) 4480 (3.8%) View
Ephrin (PF00812) 3141 (2.6%) View
hGDE_N (PF14699) 1456 (1.2%) View
COX_ARM (PF06481) 1342 (1.1%) View
PAD_N (PF08526) 945 (0.8%) View
SoxE (PF06525) 139 (0.1%) View
PixA (PF12306) 132 (0.1%) View
CzcE (PF16986) 115 (0.1%) View
DP-EP (PF08985) 32 (0.0%) View
Total: 15 Total: 118686 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...