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189  structures 6097  species 0  interactions 45687  sequences 2559  architectures

Clan: Cache (CL0165)


Cache-like domain Add an annotation

The Cache domain an extracellular domain that is thought to have a role in small-molecule recognition in a wide range of proteins, including the animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors [1]. It is homologous to, but sufficiently different from the most common intracellular sensor module, the PAS domain. Furthermore, it is suggested that it might have originated from a simpler intracellular PAS/GAF ancestor as a benefit of extracellular sensing [2].

This clan contains 23 families and the total number of domains in the clan is 45687. The clan was built by RD Finn and S El-Gebali.

Literature references

  1. Anantharaman V, Aravind L; , Trends Biochem Sci 2000;25:535-537.: Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. PUBMED:11084361 EPMC:11084361
  2. Upadhyay AA, Fleetwood AD, Adebali O, Finn RD, Zhulin IB;, PLoS Comput Biol. 2016;12:e1004862.: Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes. PUBMED:27049771 EPMC:27049771


This clan contains the following 23 member families:

2CSK_N ArlS_N Cache_3-Cache_2 CHASE CHASE4 CHASE7 CHASE8 dCache_1 dCache_2 dCache_3 Diacid_rec GAPES1 LuxQ-periplasm PhoQ_Sensor sCache_2 sCache_3_2 sCache_3_3 sCache_4 sCache_like SMP_2 Stimulus_sens_1 VGCC_alpha2 YkuI_C

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
dCache_1 (PF02743) 14842 (32.5%) View
CHASE (PF03924) 4120 (9.0%) View
sCache_3_2 (PF17203) 3835 (8.4%) View
VGCC_alpha2 (PF08473) 3761 (8.2%) View
sCache_2 (PF17200) 3626 (7.9%) View
2CSK_N (PF08521) 3591 (7.9%) View
dCache_3 (PF14827) 1452 (3.2%) View
dCache_2 (PF08269) 1386 (3.0%) View
CHASE4 (PF05228) 1229 (2.7%) View
sCache_3_3 (PF17202) 1196 (2.6%) View
Diacid_rec (PF05651) 1109 (2.4%) View
Cache_3-Cache_2 (PF17201) 1001 (2.2%) View
Pfam family Num. domains Alignment
CHASE8 (PF17152) 882 (1.9%) View
sCache_like (PF16736) 862 (1.9%) View
Stimulus_sens_1 (PF13756) 643 (1.4%) View
sCache_4 (PF09984) 612 (1.3%) View
ArlS_N (PF18719) 540 (1.2%) View
SMP_2 (PF10144) 370 (0.8%) View
YkuI_C (PF10388) 340 (0.7%) View
PhoQ_Sensor (PF08918) 128 (0.3%) View
LuxQ-periplasm (PF09308) 80 (0.2%) View
CHASE7 (PF17151) 57 (0.1%) View
GAPES1 (PF17155) 25 (0.1%) View
Total: 23 Total: 45687 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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