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189  structures 6097  species 0  interactions 45687  sequences 2559  architectures

Clan: Cache (CL0165)

Summary

Cache-like domain Add an annotation

The Cache domain an extracellular domain that is thought to have a role in small-molecule recognition in a wide range of proteins, including the animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors [1]. It is homologous to, but sufficiently different from the most common intracellular sensor module, the PAS domain. Furthermore, it is suggested that it might have originated from a simpler intracellular PAS/GAF ancestor as a benefit of extracellular sensing [2].

This clan contains 23 families and the total number of domains in the clan is 45687. The clan was built by RD Finn and S El-Gebali.

Literature references

  1. Anantharaman V, Aravind L; , Trends Biochem Sci 2000;25:535-537.: Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. PUBMED:11084361 EPMC:11084361
  2. Upadhyay AA, Fleetwood AD, Adebali O, Finn RD, Zhulin IB;, PLoS Comput Biol. 2016;12:e1004862.: Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes. PUBMED:27049771 EPMC:27049771

Members

This clan contains the following 23 member families:

2CSK_N ArlS_N Cache_3-Cache_2 CHASE CHASE4 CHASE7 CHASE8 dCache_1 dCache_2 dCache_3 Diacid_rec GAPES1 LuxQ-periplasm PhoQ_Sensor sCache_2 sCache_3_2 sCache_3_3 sCache_4 sCache_like SMP_2 Stimulus_sens_1 VGCC_alpha2 YkuI_C

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
dCache_1 (PF02743) 14842 (32.5%) View
CHASE (PF03924) 4120 (9.0%) View
sCache_3_2 (PF17203) 3835 (8.4%) View
VGCC_alpha2 (PF08473) 3761 (8.2%) View
sCache_2 (PF17200) 3626 (7.9%) View
2CSK_N (PF08521) 3591 (7.9%) View
dCache_3 (PF14827) 1452 (3.2%) View
dCache_2 (PF08269) 1386 (3.0%) View
CHASE4 (PF05228) 1229 (2.7%) View
sCache_3_3 (PF17202) 1196 (2.6%) View
Diacid_rec (PF05651) 1109 (2.4%) View
Cache_3-Cache_2 (PF17201) 1001 (2.2%) View
continued
Pfam family Num. domains Alignment
CHASE8 (PF17152) 882 (1.9%) View
sCache_like (PF16736) 862 (1.9%) View
Stimulus_sens_1 (PF13756) 643 (1.4%) View
sCache_4 (PF09984) 612 (1.3%) View
ArlS_N (PF18719) 540 (1.2%) View
SMP_2 (PF10144) 370 (0.8%) View
YkuI_C (PF10388) 340 (0.7%) View
PhoQ_Sensor (PF08918) 128 (0.3%) View
LuxQ-periplasm (PF09308) 80 (0.2%) View
CHASE7 (PF17151) 57 (0.1%) View
GAPES1 (PF17155) 25 (0.1%) View
Total: 23 Total: 45687 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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