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411  structures 6462  species 0  interactions 45618  sequences 236  architectures

Clan: ComplexI-N (CL0425)


NADH dehydrogenase I, subunit N Add an annotation

This superfamily contains proteins from the families Oxidored_q1 and NADHdeh_related. The Oxidored_q1 family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane. Many members of the NADHdeh_related family are archaeal and bacterial, indicating the evolutionary origins of ComplexI.

This clan contains 3 families and the total number of domains in the clan is 45618. The clan was built by A Bateman.


This clan contains the following 3 member families:

NADHdeh_related NADHdh Proton_antipo_M

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Proton_antipo_M (PF00361) 36719 (80.5%) View
NADHdh (PF00146) 8869 (19.4%) View
NADHdeh_related (PF10125) 30 (0.1%) View
Total: 3 Total: 45618 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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