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74  structures 5707  species 0  interactions 23138  sequences 261  architectures

Clan: DPBB (CL0199)


Double Psi beta barrel glucanase Add an annotation

The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions [1,2]. This clan represents the barwin like barrels.

This clan contains 5 families and the total number of domains in the clan is 23138. The clan was built by A Bateman.

Literature references

  1. Mizuguchi K, Dhanaraj V, Blundell TL, Murzin AG; , Structure Fold Des. 1999;7:215-216.: N-ethylmaleimide-sensitive fusion protein (NSF) and CDC48 confirmed as members of the double-psi beta-barrel aspartate decarboxylase/formate dehydrogenase family. PUBMED:10610264 EPMC:10610264
  2. Castillo RM, Mizuguchi K, Dhanaraj V, Albert A, Blundell TL, Murzin AG; , Structure Fold Des 1999;7:227-236.: A six-stranded double-psi beta barrel is shared by several protein superfamilies. PUBMED:10368289 EPMC:10368289


This clan contains the following 5 member families:

3D Barwin Cerato-platanin DPBB_1 Glyco_hydro_45

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DPBB_1 (PF03330) 15336 (66.3%) View
3D (PF06725) 5205 (22.5%) View
Cerato-platanin (PF07249) 1031 (4.5%) View
Barwin (PF00967) 863 (3.7%) View
Glyco_hydro_45 (PF02015) 703 (3.0%) View
Total: 5 Total: 23138 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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