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304  structures 1770  species 0  interactions 11149  sequences 328  architectures

Clan: Di-copper (CL0205)


Di-copper centre-containing domain Add an annotation

This superfamily includes tyrosinases and hemocyanins that share a di-copper centre [1].

This clan contains 2 families and the total number of domains in the clan is 11149. The clan was built by A Bateman.

Literature references

  1. Lerch K, Germann UA; , Prog Clin Biol Res 1988;274:331-348.: Evolutionary relationships among copper proteins containing coupled binuclear copper sites. PUBMED:3136463 EPMC:3136463


This clan contains the following 2 member families:

Hemocyanin_M Tyrosinase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tyrosinase (PF00264) 10153 (91.1%) View
Hemocyanin_M (PF00372) 996 (8.9%) View
Total: 2 Total: 11149 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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