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0  structures 261  species 0  interactions 873  sequences 176  architectures

Clan: EAD1 (CL0699)


EAD1-like clan Add an annotation

Effector-associated domains (EADs) are predicted to function as adaptor domains mediating protein-protein interactions. The EADs show a characteristic architectural pattern. One copy is always fused, typically to the N- or C-terminus, of a core component of a biological conflict system; examples include VMAP, iSTAND, or GAP1. Further copies of the same EAD are fused to either effector or signal-transducing domains, or additional EADs. EAD pairs are frequently observed together on the genome in conserved gene neighborhoods, but can also be severed from such neighborhoods and located in distant regions, indicating the EAD-EAD coupling approximates the advantages of collinear transcription. This superfamily includes several families that are related to the EAD1 family.

This clan contains 6 families and the total number of domains in the clan is 873. The clan was built by L Aravind and LM Iyer.

Literature references

  1. Kaur G, Burroughs AM, Iyer LM, Aravind L;, Elife. 2020; [Epub ahead of print]: Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity. PUBMED:32101166 EPMC:32101166


This clan contains the following 6 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EAD1 (PF19955) 375 (43.0%) View
EAD2 (PF19956) 333 (38.1%) View
EAD8 (PF19961) 62 (7.1%) View
EAD10 (PF19954) 60 (6.9%) View
EAD7 (PF19960) 41 (4.7%) View
EAD6 (PF19958) 2 (0.2%) View
Total: 6 Total: 873 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...