Summary
EGF superfamily
Members of this clan all belong to the EGF superfamily. This particular superfamily is characterised as having least 6 cysteine residues. These cysteines form disulphide bonds, in the order 1-3, 2-4, 5-6, which are essential for the stability of the EGF fold. These disulphide bonds are stacked in a ladder-like arrangement. The Laminin EGF family is distinguished by having an an additional disulphide bond. The function of the domains within this family remains unclear, but they are thought to largely perform a structural role. More often than not, these domains are arranged in tandem repeats in extracellular proteins.
This clan contains 22 families and the total number of domains in the clan is 736949. The clan was built by RD Finn and A Bateman.
Literature references
- Appella E, Weber IT, Blasi F; , FEBS Lett 1988;231:1-4.: Structure and function of epidermal growth factor-like regions in proteins. PUBMED:3282918 EPMC:3282918
- Hohenester E, Engel J; , Matrix Biol 2002;21:115-128.: Domain structure and organisation in extracellular matrix proteins. PUBMED:11852228 EPMC:11852228
Members
This clan contains the following 22 member families:
cEGF CFC DSL EGF EGF_2 EGF_3 EGF_alliinase EGF_CA EGF_MSP1_1 EGF_Tenascin Ephrin_rec_like Fibrillin_U_N FOLN FXa_inhibition Gla hEGF I-EGF_1 Laminin_EGF Plasmod_Pvs28 Sushi Sushi_2 Tme5_EGF_likeExternal database links
| CATH: | 2.10.25.10 |
| SCOP: | 57196 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| EGF_CA (PF07645) | 162547 (22.1%) | View |
| EGF (PF00008) | 154925 (21.0%) | View |
| Sushi (PF00084) | 132661 (18.0%) | View |
| Laminin_EGF (PF00053) | 114972 (15.6%) | View |
| FXa_inhibition (PF14670) | 34551 (4.7%) | View |
| hEGF (PF12661) | 32688 (4.4%) | View |
| EGF_3 (PF12947) | 22561 (3.1%) | View |
| Ephrin_rec_like (PF07699) | 18449 (2.5%) | View |
| cEGF (PF12662) | 17925 (2.4%) | View |
| EGF_Tenascin (PF18720) | 15792 (2.1%) | View |
| EGF_2 (PF07974) | 13979 (1.9%) | View |
| Gla (PF00594) | 4132 (0.6%) | View |
| continued | ||
| Pfam family | Num. domains | Alignment |
|---|---|---|
| I-EGF_1 (PF18372) | 3607 (0.5%) | View |
| DSL (PF01414) | 3538 (0.5%) | View |
| FOLN (PF09289) | 1880 (0.3%) | View |
| Fibrillin_U_N (PF18193) | 960 (0.1%) | View |
| Sushi_2 (PF09014) | 499 (0.1%) | View |
| CFC (PF09443) | 427 (0.1%) | View |
| EGF_alliinase (PF04863) | 382 (0.1%) | View |
| Tme5_EGF_like (PF09064) | 252 (0.0%) | View |
| Plasmod_Pvs28 (PF06247) | 139 (0.0%) | View |
| EGF_MSP1_1 (PF12946) | 83 (0.0%) | View |
| Total: 22 | Total: 736949 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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