WXG100-A/WXG100-B dimer

The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (PF06013), such as ESAT-10 (6 kDa early secreted antigenic target) and CFP-10 (10 kDa culture filtrate protein) in Mycobacterium tuberculosis or EsxA (ESAT-6-like extracellularly secreted protein A) and EsxB in Staphylococcus aureus. These two proteins, generally encoded in the same gene cluster, form a 1:1 heterodimeric complex. These proteins are virulence factors involved in host-pathogen interaction [1], as demonstrated in Mycobacterium tuberculosis, Staphylococcus aureus or Bacillus anthracis. The Wss is encoded in many other Gram-positive (monoderm) bacteria. This superfamily contains a number of DUFs which are closely related and may or may not represent the same family of proteins.

This clan contains 11 families and the total number of domains in the clan is 11419. The clan was built by RD Finn.

Literature references

1. Burts ML, Williams WA, DeBord K, Missiakas DM; , Proc Natl Acad Sci U S A. 2005;102:1169-1174.: EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections. PUBMED:15657139 EPMC:15657139
2. Desvaux M, Hebraud M, Talon R, Henderson IR;, Trends Microbiol. 2009;17:338-340.: Outer membrane translocation: numerical protein secretion nomenclature in question in mycobacteria. PUBMED:19674902 EPMC:19674902
3. Sutcliffe IC;, Antonie Van Leeuwenhoek. 2011;99:127-131.: New insights into the distribution of WXG100 protein secretion systems. PUBMED:20852931 EPMC:20852931
4. Desvaux M, Hebraud M, Talon R, Henderson IR;, Trends Microbiol. 2009;17:139-145.: Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. PUBMED:19299134 EPMC:19299134

Members

This clan contains the following 11 member families:

External database links

Below is a listing of the unique domain organisations or architectures from this clan. More...

The table below shows the number of occurrences of each domain throughout the sequence database. More...

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This diagram shows the relationships between members of this clan. More...

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.