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35  structures 1315  species 0  interactions 13050  sequences 236  architectures

Clan: FG_rpt (CL0647)


Nucleoporin FG repeat Add an annotation

This clan includes families which contain nucleoporin FG repeats.

This clan contains 2 families and the total number of domains in the clan is 13050. The clan was built by J Mistry.

Literature references

  1. Dolker N, Zachariae U, Grubmuller H;, Biophys J. 2010;98:2653-2661.: Hydrophilic linkers and polar contacts affect aggregation of FG repeat peptides. PUBMED:20513410 EPMC:20513410
  2. Frey S, Richter RP, Gorlich D;, Science. 2006;314:815-817.: FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties. PUBMED:17082456 EPMC:17082456


This clan contains the following 2 member families:

Nucleoporin_FG Nucleoporin_FG2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Nucleoporin_FG (PF13634) 12130 (93.0%) View
Nucleoporin_FG2 (PF15967) 920 (7.0%) View
Total: 2 Total: 13050 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...