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862  structures 9014  species 0  interactions 91467  sequences 862  architectures

Clan: FKBP (CL0487)


FKBP-like superfamily Add an annotation

This superfamily includes the FKBP domain which catalyses the peptidyl-prolyl cis-trans isomerisation reaction. The superfamily also includes the C-terminal domain of GreA and the c-terminal dmoain of 3-mercaptopyruvate sulfurtransferase.

This clan contains 11 families and the total number of domains in the clan is 91467. The clan was built by A Bateman.


This clan contains the following 11 member families:

DUF1930 DUF4827 FKBP26_C FKBP_C FKBP_N_2 GCD14_N GreA_GreB OSR1_C Rotamase Rotamase_2 Rotamase_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FKBP_C (PF00254) 47055 (51.4%) View
GreA_GreB (PF01272) 13289 (14.5%) View
Rotamase_3 (PF13616) 10763 (11.8%) View
Rotamase (PF00639) 8960 (9.8%) View
OSR1_C (PF12202) 5225 (5.7%) View
Rotamase_2 (PF13145) 4257 (4.7%) View
GCD14_N (PF14801) 1535 (1.7%) View
DUF4827 (PF16109) 171 (0.2%) View
FKBP_N_2 (PF18023) 107 (0.1%) View
FKBP26_C (PF18046) 86 (0.1%) View
DUF1930 (PF09122) 19 (0.0%) View
Total: 11 Total: 91467 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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