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13  structures 1552  species 0  interactions 20605  sequences 488  architectures

Clan: G-PATCH (CL0449)


DExH-box splicing factor binding site Add an annotation

This superfamily is characterised by domains which are related to the G-patch domain in proteins with RNA-binding/splicing activity. This domain affects RNA-splicing by binding to a DExH-box splicing factor.

This clan contains 2 families and the total number of domains in the clan is 20605. The clan was built by P Coggill.

Literature references

  1. Silverman EJ, Maeda A, Wei J, Smith P, Beggs JD, Lin RJ;, Mol Cell Biol. 2004;24:10101-10110.: Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing. PUBMED:15542821 EPMC:15542821
  2. Boon KL, Auchynnikava T, Edwalds-Gilbert G, Barrass JD, Droop AP, Dez C, Beggs JD;, Mol Cell Biol. 2006;26:6016-6023.: Yeast ntr1/spp382 mediates prp43 function in postspliceosomes. PUBMED:16880513 EPMC:16880513


This clan contains the following 2 member families:

G-patch G-patch_2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
G-patch (PF01585) 19048 (92.4%) View
G-patch_2 (PF12656) 1557 (7.6%) View
Total: 2 Total: 20605 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...