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61  structures 1555  species 0  interactions 17405  sequences 163  architectures

Clan: GCP (CL0540)


Gamma-tubulin complex superfamily Add an annotation

This superfamily carries families of proteins all derived via gene-duplication events that act together in the gamma-tubulin complex. This complex is required for microtubule nucleation at the centrosome.

This clan contains 3 families and the total number of domains in the clan is 17405. The clan was built by P Coggill.

Literature references

  1. Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T;, Mol Biol Cell. 2001;12:3340-3352.: GCP5 and GCP6: two new members of the human gamma-tubulin complex. PUBMED:11694571 EPMC:11694571


This clan contains the following 3 member families:

GCP5-Mod21 GCP_C_terminal GCP_N_terminal

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GCP_C_terminal (PF04130) 8843 (50.8%) View
GCP_N_terminal (PF17681) 8558 (49.2%) View
GCP5-Mod21 (PF14609) 4 (0.0%) View
Total: 3 Total: 17405 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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